Jeffrey D Esko Selected Research

Heparitin Sulfate (Heparan Sulfate)

1/2022	Multiplex genome editing of mammalian cells for producing recombinant heparin.
1/2022	Impaired mitophagy in Sanfilippo a mice causes hypertriglyceridemia and brown adipose tissue activation.
10/2021	Endothelial Heparan Sulfate Mediates Hepatic Neutrophil Trafficking and Injury during Staphylococcus aureus Sepsis.
11/2020	SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2.
7/2020	SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2.
1/2020	Prion protein post-translational modifications modulate heparan sulfate binding and limit aggregate size in prion disease.
1/2020	Shortening heparan sulfate chains prolongs survival and reduces parenchymal plaques in prion disease caused by mobile, ADAM10-cleaved prions.
1/2019	Hepatic heparan sulfate is a master regulator of hepcidin expression and iron homeostasis in human hepatocytes and mice.
1/2018	Downstream Products are Potent Inhibitors of the Heparan Sulfate 2-O-Sulfotransferase.
1/2018	Surfen and oxalyl surfen decrease tau hyperphosphorylation and mitigate neuron deficits in vivo in a zebrafish model of tauopathy.

For more, sign up at right for free...

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Jeffrey D Esko Research Topics

Disease

17	Inflammation (Inflammations) 10/2021 - 07/2002
16	Infections 12/2021 - 05/2002
15	Neoplasms (Cancer) 01/2022 - 01/2002
11	Mucopolysaccharidoses 01/2022 - 03/2011
7	Hypertriglyceridemia 01/2019 - 06/2008
7	Neoplasm Metastasis (Metastasis) 02/2009 - 01/2002
6	COVID-19 12/2021 - 07/2020
6	Atherosclerosis 01/2020 - 11/2009
5	Hyperlipidemias (Hyperlipidemia) 01/2020 - 06/2008
5	Cardiovascular Diseases (Cardiovascular Disease) 10/2019 - 06/2008
4	Sepsis (Septicemia) 10/2021 - 01/2012
4	Prion Diseases (Transmissible Spongiform Encephalopathies) 01/2020 - 10/2003
3	Mucopolysaccharidosis III (Sanfilippo Syndrome) 01/2022 - 10/2012
3	Malaria 12/2021 - 11/2007
3	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2020 - 01/2017
3	Hepatocellular Carcinoma (Hepatoma) 01/2019 - 01/2012
3	Mucopolysaccharidosis I (Hurler Syndrome) 12/2017 - 08/2014
3	Multiple Hereditary Exostoses (Hereditary Multiple Exostoses) 03/2013 - 12/2002
3	Peritonitis 05/2007 - 07/2002
3	Adenocarcinoma 05/2007 - 06/2003
2	Mastocytoma 01/2022 - 03/2014
2	Dyslipidemias (Dyslipidemia) 01/2022 - 05/2010
2	Hypoxia (Hypoxemia) 01/2022 - 01/2014
2	Thrombocytopenia (Thrombopenia) 12/2021 - 09/2011
2	Virus Diseases (Viral Diseases) 01/2021 - 01/2006
2	Tauopathies 12/2020 - 01/2018
2	Leukemia 11/2020 - 02/2009
2	Disease Progression 01/2020 - 01/2020
2	Respiratory Hypersensitivity 01/2018 - 09/2009
2	Pathologic Processes 01/2018 - 02/2009
2	Obesity 03/2015 - 11/2014
2	Asthma (Bronchial Asthma) 08/2014 - 09/2009
2	Exostoses 05/2011 - 11/2005
2	Lewis Lung Carcinoma 02/2009 - 05/2006
2	Carcinoma (Carcinomatosis) 05/2007 - 06/2003
1	Cachexia 01/2022
1	Breast Neoplasms (Breast Cancer) 01/2022
1	Hyperphagia (Overeating) 01/2022
1	Hyperthermia 01/2022
1	Thrombosis (Thrombus) 01/2022

Drug/Important Bio-Agent (IBA)

42	Heparitin Sulfate (Heparan Sulfate)IBA 01/2022 - 01/2002
21	Proteins (Proteins, Gene)FDA Link 01/2022 - 05/2002
16	EnzymesIBA 01/2020 - 02/2005
13	GlycosaminoglycansIBA 01/2022 - 10/2003
13	Heparin (Liquaemin)FDA LinkGeneric 01/2022 - 05/2002
12	Heparan Sulfate Proteoglycans (Heparan Sulfate Proteoglycan)IBA 01/2020 - 01/2002
10	Polysaccharides (Glycans)IBA 01/2020 - 07/2005
8	Proteoglycans (Proteoglycan)IBA 09/2021 - 01/2006
8	Triglycerides (Triacylglycerol)IBA 01/2019 - 06/2008
7	Chondroitin Sulfates (Chondroitin Sulfate)IBA 01/2022 - 01/2002
7	AnticoagulantsIBA 01/2022 - 05/2007
6	SulfotransferasesIBA 11/2014 - 09/2005
6	SelectinsIBA 02/2009 - 07/2002
5	Biomarkers (Surrogate Marker)IBA 01/2021 - 01/2012
5	Pharmaceutical PreparationsIBA 01/2021 - 07/2005
5	Lipoproteins (Lipoprotein)IBA 01/2019 - 06/2008
4	AcetylglucosamineIBA 01/2022 - 09/2005
4	aminoquinuride (Surfen)IBA 12/2020 - 09/2008
4	PrionsIBA 01/2020 - 10/2003
4	ChemokinesIBA 01/2018 - 09/2005
4	Sialyl Lewis X AntigenIBA 02/2009 - 06/2003
4	DisaccharidesIBA 02/2009 - 06/2003
4	LigandsIBA 05/2006 - 05/2002
3	N-sulfoglucosamine sulfohydrolase (sulfamidase)IBA 01/2022 - 01/2017
3	ProteomeIBA 10/2021 - 01/2019
3	Biological ProductsIBA 11/2020 - 01/2010
3	LyasesIBA 11/2020 - 07/2020
3	AllergensIBA 01/2018 - 09/2009
3	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2018 - 05/2007
3	CholesterolIBA 03/2015 - 05/2010
3	Sulfates (Sulfates, Inorganic)IBA 08/2014 - 09/2005
3	P-SelectinIBA 05/2006 - 06/2003
2	Platelet Factor 4IBA 12/2021 - 09/2011
2	ChondroitinIBA 12/2021 - 02/2014
2	Chondroitin Sulfate ProteoglycansIBA 12/2020 - 01/2017
2	Glucuronic Acid (Glucuronate)IBA 01/2020 - 05/2007
2	ArylsulfatasesIBA 01/2020 - 06/2012
2	Prion ProteinsIBA 01/2020 - 01/2020
2	Apolipoprotein C-IIIIBA 10/2019 - 01/2016
2	Glycoproteins (Glycoprotein)IBA 01/2018 - 09/2008
2	Iduronidase (alpha-L-Iduronidase)IBA 12/2017 - 01/2016
2	Apolipoproteins E (ApoE)IBA 03/2015 - 06/2013
2	CarbohydratesIBA 01/2012 - 05/2006
2	LipopolysaccharidesIBA 01/2012 - 05/2007
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2008 - 06/2003
2	L-SelectinIBA 05/2007 - 09/2005
2	(Ac)(6)GlcNAcbeta1,3Galbeta- O- naphthalenemethanolIBA 05/2006 - 06/2003
2	GlycosidesIBA 05/2006 - 06/2003
2	adhesion receptorIBA 05/2006 - 06/2003
2	Heparinoids (Heparinoid)IBA 09/2005 - 07/2002
2	MucinsIBA 06/2003 - 06/2003
1	TrioleinIBA 01/2022
1	CalpainIBA 01/2022
1	Lactic Acid (Lactate)FDA LinkGeneric 01/2022
1	O-GlcNAc transferaseIBA 01/2022
1	Ryanodine Receptor Calcium Release Channel (Ryanodine Receptor)IBA 01/2022
1	Peptide Hydrolases (Proteases)FDA Link 01/2022

Therapy/Procedure

11	Therapeutics 12/2021 - 01/2002
3	Enzyme Replacement Therapy 12/2017 - 10/2012
2	Hematopoietic Stem Cell Transplantation 01/2016 - 08/2014